Publications

Clinical Approach to Genetic Cerebral Arteriopathy in the Adult Patient With Ischemic Stroke

Eliot N. Haddad, Pranav Kumar, Galen Shearn-Nance, G. Abbas Kharal, Andrew Dhawan

Neurology Genetics · 01 Oct 2024 · doi:10.1212/NXG.0000000000200182

Ryan G. Rilinger, Lydia Guo, Akshay Sharma, Josephine Volovetz, Nicolas R. Thompson, Matthew Grabowski, Mina Lobbous, Andrew Dhawan

Journal of Neuro-Oncology · 05 Aug 2024 · doi:10.1007/s11060-024-04787-z

Homologous recombination promotes mitotic death to suppress the innate immune response

Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna Gonzalez Manjon, Andrew Dhawan, ..., Scott G. Page, Eric Hau, Hilda A. Pickett, Harriet E. Gee, Anthony J. Cesare

Cold Spring Harbor Laboratory · 06 May 2024 · doi:10.1101/2024.05.04.592546

Exploring the neurological features of individuals with germline PTEN variants: A multicenter study

Andrew Dhawan, Sarah Baitamouni, Darren Liu, Robyn Busch, Patricia Klaas, ..., David M. Ritter, Antonio Y. Hardan, Julian A. Martinez‐Agosto, Mustafa Sahin, Charis Eng

Annals of Clinical and Translational Neurology · 19 Mar 2024 · doi:10.1002/acn3.52046

Neurology and climate change: What we know and where we are going

Jonathan Doan, Andrew Dhawan

The Journal of Climate Change and Health · 01 Mar 2024 · doi:10.1016/j.joclim.2023.100284

Is theMTHFRgene mutation associated with thrombosis?

Andrew Dhawan, Charis Eng

Cleveland Clinic Journal of Medicine · 01 Nov 2023 · doi:10.3949/ccjm.90a.23044

Exploiting convergent phenotypes to derive a pan-cancer cisplatin response gene expression signature

Jessica A. Scarborough, Steven A. Eschrich, Javier Torres-Roca, Andrew Dhawan, Jacob G. Scott

npj Precision Oncology · 19 Apr 2023 · doi:10.1038/s41698-023-00375-y

Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice

Shreya Louis, Alise K. Carlson, Abhilash Suresh, Joshua Rim, MaryAnn Mays, Daniel Ontaneda, Andrew Dhawan

Neurology · 07 Mar 2023 · doi:10.1212/WNL.0000000000201630

Phase IIa Study of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma

Manmeet S. Ahluwalia, David A. Reardon, Ajay P. Abad, William T. Curry, Eric T. Wong, ..., Andrew Dhawan, Meaghan T. Birkemeier, Danielle M. Casucci, Michael J. Ciesielski, Robert A. Fenstermaker

Journal of Clinical Oncology · 01 Mar 2023 · doi:10.1200/JCO.22.00996

EGFR Pathway Expression Persists in Recurrent Glioblastoma Independent of Amplification Status

Andrew Dhawan, Venkata S. K. Manem, Gabrielle Yeaney, Justin D. Lathia, Manmeet S. Ahluwalia

Cancers · 21 Jan 2023 · doi:10.3390/cancers15030670

Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signature

Jacob Scott, Jessica Scarborough, Steven Eschrich, Javier Torres-Roca, Andrew Dhawan

Research Square Platform LLC · 17 Oct 2022 · doi:10.21203/rs.3.rs-2121659/v1

First clinical experience with belzutifan in von Hippel–Lindau disease associated CNS hemangioblastoma

Andrew Dhawan, David M Peereboom, Glen HJ Stevens

CNS Oncology · 12 Jul 2022 · doi:10.2217/cns-2022-0008

Machine Learning Using Gene-Sets to Infer miRNA Function

Andrew Dhawan, Francesca M. Buffa

Advances in Experimental Medicine and Biology · 01 Jan 2022 · doi:10.1007/978-3-031-08356-3_8

Neurology in a Changing Climate: A Scoping Review

Shreya Louis, Alise Carlson, Abhilash Suresh, Joshua Rim, MaryAnn Mays, Daniel Ontaneda, Andrew Dhawan

Cold Spring Harbor Laboratory · 26 Nov 2021 · doi:10.1101/2021.11.24.21266840

Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signature

Jessica A. Scarborough, Steven A. Eschrich, Javier Torres-Roca, Andrew Dhawan, Jacob G. Scott

Cold Spring Harbor Laboratory · 11 Nov 2021 · doi:10.1101/2021.11.10.21265799

Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma

Davis T. Weaver, Kathleen I. Pishas, Drew Williamson, Jessica Scarborough, Stephen L. Lessnick, Andrew Dhawan, Jacob G. Scott

PLOS Computational Biology · 18 Oct 2021 · doi:10.1371/journal.pcbi.1008755

Extracellular Mirna Biomarkers in Neurologic Disease: Is Cerebrospinal Fluid Helpful?

Andrew Dhawan

Biomarkers in Medicine · 13 Sep 2021 · doi:10.2217/bmm-2021-0092

Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNA

L. Winchester, L. van Bijsterveldt, A. Dhawan, S. Wigfield, C. Triantafyllidis, S. Haider, A. McIntyre, T.C. Humphrey, A.L. Harris, F.M. Buffa

Cold Spring Harbor Laboratory · 31 Aug 2021 · doi:10.1101/2021.08.30.458145

UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic

Davis T. Weaver, Benjamin D. McElvany, Vishhvaan Gopalakrishnan, Kyle J. Card, Dena Crozier, ..., Geoff Sedor, Enze Tian, Gary C. An, Sean A. Diehl, Jacob G. Scott

PLOS ONE · 26 Jul 2021 · doi:10.1371/journal.pone.0241734

Mathematical Modeling of ceRNA-Based Interactions

Andrew Dhawan

Methods in Molecular Biology · 01 Jan 2021 · doi:10.1007/978-1-0716-1503-4_7

Continuous electroencephalography characteristics and acute symptomatic seizures in COVID-19 patients

Shreya Louis, Andrew Dhawan, Christopher Newey, Dileep Nair, Lara Jehi, Stephen Hantus, Vineet Punia

Clinical Neurophysiology · 01 Nov 2020 · doi:10.1016/j.clinph.2020.08.003

Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma

Jessica A. Scarborough, Erin McClure, Peter Anderson, Andrew Dhawan, Arda Durmaz, Stephen L. Lessnick, Masahiro Hitomi, Jacob G. Scott

iScience · 01 Jul 2020 · doi:10.1016/j.isci.2020.101293

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer

Andrew Dhawan, Jacob Scott, Purnima Sundaresan, Michael Veness, Sandro Porceddu, Eric Hau, Adrian L. Harris, Francesca M. Buffa, Harriet E. Gee

Scientific Reports · 23 Jun 2020 · doi:10.1038/s41598-020-66983-x

Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures in COVID-19 Patients

Shreya Louis, Andrew Dhawan, Christopher Newey, Dileep Nair, Lara Jehi, Stephen Hantus, Vineet Punia

Cold Spring Harbor Laboratory · 28 May 2020 · doi:10.1101/2020.05.26.20114033

A super-series of extracellular miRNA in cerebrospinal fluid reveals broad patterns associated with neurologic disease

Andrew Dhawan

Cold Spring Harbor Laboratory · 23 May 2020 · doi:10.1101/2020.05.20.20108472

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, ..., Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk

Nature Communications · 14 May 2020 · doi:10.1038/s41467-020-16212-w

Mathematical oncology and it’s application in non melanoma skin cancer – A primer for radiation oncology professionals

Noel J. Aherne, Andrew Dhawan, Jacob G. Scott, Heiko Enderling

Oral Oncology · 01 Apr 2020 · doi:10.1016/j.oraloncology.2019.104473

UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the COVID-19 Pandemic

Kyle J. Card, Dena Crozier, Andrew Dhawan, Mina N. Dinh, Emily Dolson, ..., Jessica A. Scarborough, Jacob G. Scott, Geoff Sedor, Enze Tian, Davis T. Weaver

Cold Spring Harbor Laboratory · 27 Mar 2020 · doi:10.1101/2020.03.25.20043489

Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewing’s sarcoma

Jessica A. Scarborough, Erin McClure, Peter Anderson, Andrew Dhawan, Arda Durmaz, Stephen L. Lessnick, Masahiro Hitomi, Jacob G. Scott

Cold Spring Harbor Laboratory · 12 Feb 2020 · doi:10.1101/2020.02.11.943936

A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety

Aaron Goldman, Joshua L. Smalley, Meeta Mistry, Harald Krenzlin, Hong Zhang, ..., Barbara Caldarone, Stephen J. Moss, David A. Silbersweig, Sean E. Lawler, Ilana M. Braun

Translational Psychiatry · 09 Dec 2019 · doi:10.1038/s41398-019-0677-1

Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma

Davis T. Weaver, Kathleen I. Pishas, Drew Williamson, Jessica Scarborough, Stephen L. Lessnick, Andrew Dhawan, Jacob G. Scott

Cold Spring Harbor Laboratory · 27 Nov 2019 · doi:10.1101/854695

Miscellaneous Metastases

Andrew Dhawan, David Peereboom

Central Nervous System Metastases · 06 Nov 2019 · doi:10.1007/978-3-030-23417-1_23

Brain Metastases from Lung Tumors

Andrew Dhawan, Manmeet Ahluwalia

Central Nervous System Metastases · 06 Nov 2019 · doi:10.1007/978-3-030-23417-1_20

RadiationGeneSigDB: a database of oxic and hypoxic radiation response gene signatures and their utility in pre-clinical research

Venkata SK Manem, Andrew Dhawan

The British Journal of Radiology · 01 Nov 2019 · doi:10.1259/bjr.20190198

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network

Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott

Journal of Theoretical Biology · 01 Nov 2019 · doi:10.1016/j.jtbi.2018.10.055

Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer

Morgan Craig, Kamran Kaveh, Alec Woosley, Andrew S. Brown, David Goldman, ..., Kazuya Arai, M. Mamunur Rahman, Sidi Chen, Martin A. Nowak, Aaron Goldman

PLOS Computational Biology · 26 Aug 2019 · doi:10.1371/journal.pcbi.1007278

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

Aaron Goldman, Sachin Khiste, Elizaveta Freinkman, Andrew Dhawan, Biswanath Majumder, ..., Takaharu Ichimura, Kodaganur S. Gopinath, Pradip Majumder, Mohammad Kohandel, Shiladitya Sengupta

Science Signaling · 20 Aug 2019 · doi:10.1126/scisignal.aas8779

Guidelines for using sigQC for systematic evaluation of gene signatures

Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa

Nature Protocols · 10 Apr 2019 · doi:10.1038/s41596-019-0136-8

Recasting the Cancer Stem Cell Hypothesis: Unification Using a Continuum Model of Microenvironmental Forces

Jacob G. Scott, Andrew Dhawan, Anita Hjelmeland, Justin Lathia, Anastasia Chumakova, Masahiro Hitomi, Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson

Current Stem Cell Reports · 15 Feb 2019 · doi:10.1007/s40778-019-0153-0

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, ..., Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk

Cold Spring Harbor Laboratory · 25 Dec 2018 · doi:10.1101/504837

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa

Nature Communications · 07 Dec 2018 · doi:10.1038/s41467-018-07657-1

RadiationGeneSigDB: A database of oxic and hypoxic radiation response gene signatures and their utility in identification of hypoxia-regulated MicroRNA

Venkata SK. Manem, Andrew Dhawan

Cold Spring Harbor Laboratory · 29 Oct 2018 · doi:10.1101/455345

TDAstats: R pipeline for computing persistent homology in topological data analysis

Raoul R. Wadhwa, Drew F.K. Williamson, Andrew Dhawan, Jacob G. Scott

Journal of Open Source Software · 08 Aug 2018 · doi:10.21105/joss.00860

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network

Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott

Cold Spring Harbor Laboratory · 31 Mar 2018 · doi:10.1101/292029

Simulated ablation for detection of cells impacting paracrine signalling in histology analysis

Jake P Taylor–King, Etienne Baratchart, Andrew Dhawan, Elizabeth A Coker, Inga Hansine Rye, Hege Russnes, S Jon Chapman, David Basanta, Andriy Marusyk

Mathematical Medicine and Biology: A Journal of the IMA · 14 Feb 2018 · doi:10.1093/imammb/dqx022

A flat persistence diagram for improved visualization of persistent homology

Raoul R. Wadhwa, Andrew Dhawan, Drew F. K. Williamson, Jacob G. Scott

arXiv · 01 Jan 2018 · doi:10.48550/arxiv.1812.04567

Pan-cancer characterisation of microRNA with hallmarks of cancer reveals role of microRNA-mediated downregulation of tumour suppressor genes

Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa

Cold Spring Harbor Laboratory · 22 Dec 2017 · doi:10.1101/238675

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia

Artem Kaznatcheev, David Robert Grimes, Robert Vander Velde, Vincent Cannataro, Etienne Baratchart, ..., Jake P. Taylor-King, Nara Yoon, Eric Padron, Andriy Marusyk, David Basanta

Cold Spring Harbor Laboratory · 30 Oct 2017 · doi:10.1101/211151

sigQC: A procedural approach for standardising the evaluation of gene signatures

Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa

Cold Spring Harbor Laboratory · 16 Oct 2017 · doi:10.1101/203729

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces

Jacob G. Scott, Andrew Dhawan, Anita Hjelmeland, Justin Lathia, Anastasia Chumakova, Masahiro Hitomi, Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson

Cold Spring Harbor Laboratory · 28 Jul 2017 · doi:10.1101/169615

Modelling recurrence and second cancer risks induced by proton therapy

V S K Manem, A Dhawan

Mathematical Medicine and Biology: A Journal of the IMA · 04 Jul 2017 · doi:10.1093/IMAMMB/DQX006

Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer

Andrew Dhawan, Daniel Nichol, Fumi Kinose, Mohamed E. Abazeed, Andriy Marusyk, Eric B. Haura, Jacob G. Scott

Scientific Reports · 27 Apr 2017 · doi:10.1038/s41598-017-00791-8

Are Patients With Loeys-Dietz Syndrome Misdiagnosed With Beals Syndrome?

Rebecca Woolnough, Andrew Dhawan, Kimberly Dow, Jagdeep S. Walia

Pediatrics · 01 Mar 2017 · doi:10.1542/peds.2016-1281

Simulated Ablation for Detection of Cells Impacting Paracrine Signalling in Histology Analysis

Jake P. Taylor-King, Etienne Baratchart, Andrew Dhawan, Elizabeth A. Coker, Inga Hansine Rye, Hege Russnes, S. Jon Chapman, David Basanta, Andriy Marusyk

arXiv · 01 Jan 2017 · doi:10.48550/arxiv.1704.04454