Tabula Rasa Lab

Research

See our published work:

2023

Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice
Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice
Shreya Louis, Alise K. Carlson, Abhilash Suresh, Joshua Rim, MaryAnn Mays, Daniel Ontaneda, Andrew Dhawan
Neurology   ·   07 Mar 2023   ·   doi:10.1212/WNL.0000000000201630
EGFR Pathway Expression Persists in Recurrent Glioblastoma Independent of Amplification Status
EGFR Pathway Expression Persists in Recurrent Glioblastoma Independent of Amplification Status
Andrew Dhawan, Venkata S. K. Manem, Gabrielle Yeaney, Justin D. Lathia, Manmeet S. Ahluwalia
Cancers   ·   21 Jan 2023   ·   doi:10.3390/cancers15030670

2022

First clinical experience with belzutifan in von Hippel–Lindau disease associated CNS hemangioblastoma
First clinical experience with belzutifan in von Hippel–Lindau disease associated CNS hemangioblastoma
Andrew Dhawan, David M Peereboom, Glen HJ Stevens
CNS Oncology   ·   01 Sep 2022   ·   doi:10.2217/cns-2022-0008

2021

Neurology in a Changing Climate: A Scoping Review
Neurology in a Changing Climate: A Scoping Review
Shreya Louis, Alise Carlson, Abhilash Suresh, Joshua Rim, MaryAnn Mays, Daniel Ontaneda, Andrew Dhawan
Cold Spring Harbor Laboratory   ·   26 Nov 2021   ·   doi:10.1101/2021.11.24.21266840
Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signature
Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signature
Jessica A. Scarborough, Steven A. Eschrich, Javier Torres-Roca, Andrew Dhawan, Jacob G. Scott
Cold Spring Harbor Laboratory   ·   11 Nov 2021   ·   doi:10.1101/2021.11.10.21265799
Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma
Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma
Davis T. Weaver, Kathleen I. Pishas, Drew Williamson, Jessica Scarborough, Stephen L. Lessnick, Andrew Dhawan, Jacob G. Scott
PLOS Computational Biology   ·   18 Oct 2021   ·   doi:10.1371/journal.pcbi.1008755
Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?
Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?
Andrew Dhawan
Biomarkers in Medicine   ·   01 Oct 2021   ·   doi:10.2217/bmm-2021-0092
UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic
UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic
Davis T. Weaver, Benjamin D. McElvany, Vishhvaan Gopalakrishnan, Kyle J. Card, Dena Crozier, ..., Geoff Sedor, Enze Tian, Gary C. An, Sean A. Diehl, Jacob G. Scott
PLOS ONE   ·   26 Jul 2021   ·   doi:10.1371/journal.pone.0241734

2020

Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma
Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma
Jessica A. Scarborough, Erin McClure, Peter Anderson, Andrew Dhawan, Arda Durmaz, Stephen L. Lessnick, Masahiro Hitomi, Jacob G. Scott
iScience   ·   01 Jul 2020   ·   doi:10.1016/j.isci.2020.101293
Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer
Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer
Andrew Dhawan, Jacob Scott, Purnima Sundaresan, Michael Veness, Sandro Porceddu, Eric Hau, Adrian L. Harris, Francesca M. Buffa, Harriet E. Gee
Scientific Reports   ·   23 Jun 2020   ·   doi:10.1038/s41598-020-66983-x
Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures in COVID-19 Patients
Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures in COVID-19 Patients
Shreya Louis, Andrew Dhawan, Christopher Newey, Dileep Nair, Lara Jehi, Stephen Hantus, Vineet Punia
Cold Spring Harbor Laboratory   ·   28 May 2020   ·   doi:10.1101/2020.05.26.20114033
A super-series of extracellular miRNA in cerebrospinal fluid reveals broad patterns associated with neurologic disease
A super-series of extracellular miRNA in cerebrospinal fluid reveals broad patterns associated with neurologic disease
Andrew Dhawan
Cold Spring Harbor Laboratory   ·   23 May 2020   ·   doi:10.1101/2020.05.20.20108472
Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, ..., Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk
Nature Communications   ·   14 May 2020   ·   doi:10.1038/s41467-020-16212-w
UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the COVID-19 Pandemic
UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the COVID-19 Pandemic
Kyle J. Card, Dena Crozier, Andrew Dhawan, Mina N. Dinh, Emily Dolson, ..., Jessica A. Scarborough, Jacob G. Scott, Geoff Sedor, Enze Tian, Davis T. Weaver
Cold Spring Harbor Laboratory   ·   27 Mar 2020   ·   doi:10.1101/2020.03.25.20043489

2019

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott
Journal of Theoretical Biology   ·   01 Nov 2019   ·   doi:10.1016/j.jtbi.2018.10.055
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer
Morgan Craig, Kamran Kaveh, Alec Woosley, Andrew S. Brown, David Goldman, ..., Kazuya Arai, M. Mamunur Rahman, Sidi Chen, Martin A. Nowak, Aaron Goldman
PLOS Computational Biology   ·   26 Aug 2019   ·   doi:10.1371/journal.pcbi.1007278
Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance
Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance
Aaron Goldman, Sachin Khiste, Elizaveta Freinkman, Andrew Dhawan, Biswanath Majumder, ..., Takaharu Ichimura, Kodaganur S. Gopinath, Pradip Majumder, Mohammad Kohandel, Shiladitya Sengupta
Science Signaling   ·   20 Aug 2019   ·   doi:10.1126/scisignal.aas8779
Guidelines for using sigQC for systematic evaluation of gene signatures
Guidelines for using sigQC for systematic evaluation of gene signatures
Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Nature Protocols   ·   10 Apr 2019   ·   doi:10.1038/s41596-019-0136-8

2018

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Nature Communications   ·   07 Dec 2018   ·   doi:10.1038/s41467-018-07657-1
TDAstats: R pipeline for computing persistent homology in topological data analysis
TDAstats: R pipeline for computing persistent homology in topological data analysis
Raoul R. Wadhwa, Drew F.K. Williamson, Andrew Dhawan, Jacob G. Scott
Journal of Open Source Software   ·   08 Aug 2018   ·   doi:10.21105/joss.00860
Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott
Cold Spring Harbor Laboratory   ·   31 Mar 2018   ·   doi:10.1101/292029

2017

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces
Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces
Jacob G. Scott, Andrew Dhawan, Anita Hjelmeland, Justin Lathia, Anastasia Chumakova, Masahiro Hitomi, Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson
Cold Spring Harbor Laboratory   ·   28 Jul 2017   ·   doi:10.1101/169615
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer
Andrew Dhawan, Daniel Nichol, Fumi Kinose, Mohamed E. Abazeed, Andriy Marusyk, Eric B. Haura, Jacob G. Scott
Scientific Reports   ·   27 Apr 2017   ·   doi:10.1038/s41598-017-00791-8

2016

Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer
Andrew Dhawan, Daniel Nichol, Fumi Kinose, Mohamed E. Abazeed, Andriy Marusyk, Eric B. Haura, Jacob G. Scott
Cold Spring Harbor Laboratory   ·   19 Sep 2016   ·   doi:10.1101/075846